Treatment of New World cutaneous leishmaniasis with miltefosine
نویسندگان
چکیده
منابع مشابه
Miltefosine for new world cutaneous leishmaniasis.
The oral agent miltefosine has demonstrated a >95% cure rate in Indian visceral leishmaniasis. We performed a large, placebo-controlled study of miltefosine therapy (2.5 mg/kg per day orally for 28 days) against cutaneous leishmaniasis in Colombia and Guatemala. In regions in Colombia where Leishmania vianna panamensis is common, the per-protocol cure rates for miltefosine and placebo were 91% ...
متن کاملResolution of Cutaneous Old World and New World Leishmaniasis after Oral Miltefosine Treatment
An Afghan migrant who had returned from a visit to the Middle East 2 years before was seen with a non-healing painless lesion on the forearm ( Figure 1A ). A skin biopsy showed intracellular Leishmania parasites in the subcutis ( Figure 1B and C ), and the polymerase chain reaction (PCR) was positive for Leishmania tropica . At the same time, a German traveler who had returned from a vacation t...
متن کاملPharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients.
The pharmacokinetics of miltefosine in leishmaniasis patients are, to a great extent, unknown. We examined and characterized the pharmacokinetics of miltefosine in a group of patients with Old World (Leishmania major) cutaneous leishmaniasis. Miltefosine plasma concentrations were determined in samples taken during and up to 5 months after the end of treatment from 31 Dutch military personnel w...
متن کاملTreatment of Bolivian mucosal leishmaniasis with miltefosine.
BACKGROUND Although mucosal leishmaniasis is a prominent disease, it has been studied only to a limited extent. It is classically treated with parenteral antimony or, as a last resort, amphotericin B. METHODS We treated Bolivian mucosal leishmaniasis due to Leishmania braziliensis with the oral agent miltefosine, 2.5 mg/kg/day for 28 days, and followed-up for 12 months. RESULTS Seventy-two ...
متن کاملPharmacokinetics of Miltefosine in Children and Adults with Cutaneous Leishmaniasis
An open-label pharmacokinetics (PK) clinical trial was conducted to comparatively assess the PK and explore the pharmacodynamics (PD) of miltefosine in children and adults with cutaneous leishmaniasis (CL) in Colombia. Sixty patients, 30 children aged 2 to 12 years and 30 adults aged 18 to 60 years, were enrolled. Participants received miltefosine (Impavido) at a nominal dose of 2.5 mg/kg/day f...
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ژورنال
عنوان ژورنال: Transactions of the Royal Society of Tropical Medicine and Hygiene
سال: 2006
ISSN: 0035-9203
DOI: 10.1016/j.trstmh.2006.02.022